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Scientific Evidence

Exploring the Scientific Potential of MegaCro™ Gardenia

MegaCro™ is actively engaging in a series of clinical trials and fundamental research aimed at comprehensively understanding the potential benefits of Gardenia jasminoides Ellis. The Gardenia extract, enriched with crocetin, has undergone rigorous evaluation in various clinical trials. Moreover, MegaCro™ has established partnerships with leading academic and research institutions to conduct comprehensive studies, facilitating a deeper understanding of its efficacy and mechanisms of action.

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Promote Eye Development

MegaCro™ Gardenia showed cell growth-promoting effect on HSFs cell, surpassing market gardenia extract by 20%, which beneficial to promote the development of healthy eyes.

Myopia Control

MegaCro™ Gardenia reduced IL-6 expression compared to control under low O2 condition, which contribute to myopia control.

Literature Reviews for Crocetin

Previous research on the safety of dietary crocetin indicated no adverse effects in adults who received oral doses ranging from 7.5 mg to 22.5 mg.1 Building on these findings, a randomized, double-blind, placebo-controlled clinical study, 69 subjects between ages of 6 and 12 years to assess the impact of dietary supplementation of crocetin on myopia control in children. This study observed no adverse effects in children when a dosage of 7.5 mg of crocetin was administered during the experimental period. These findings highlight the safety profile of crocetin supplementation in children and provide scientific evidence supporting its potential role in myopia control.2

1. Phytomedicine. 2011 May 15;18(7):575-8.
DOI: 10.1016/j.phymed.2010.10.019.
2. Journal of Clinical Medicine. 2019 Aug 7;8(8):1179.
DOI: 10.3390/jcm8081179.